Hoffman et al. presented the patient-reported outcomes of 173 men with localized prostate cancer who were treated at M.D. Anderson in Houston. They were randomized to receive either:
- 75.6 Gy in 42 fractions (conventional fractionation) via IMRT
- 72 Gy in 30 fractions (hypofractionation) via IMRT
- there was no difference with regard to rectal issues (urgency, control, frequency, or bleeding).
- there was no difference with regard to urinary issues (pain, blood in urine, waking to urinate at night, or leakage)
- there was no difference with regard to sexual issues (erections firm enough for intercourse)
- there were no differences at 2, 3, 4, or 5 years.