tag:blogger.com,1999:blog-5068743626565397624.post4817565532443602983..comments2024-03-19T00:22:37.279-07:00Comments on Prostate Cancer News, Reviews & Views: Ac-225-PSMA-617 (update)Allenhttp://www.blogger.com/profile/02930631057044153073noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-5068743626565397624.post-55611550013824424662019-05-20T14:57:57.157-07:002019-05-20T14:57:57.157-07:00Telix Pharmaceuticals has recently announced compl...Telix Pharmaceuticals has recently announced completion of a phase II trial that shows low but frequent doses of their 177Lu-huJ591 can be effective "with no irradiation of salivary and lacrimal glands." <br /><br />http://www.telixpharma.com/investors/asx-announcements/<br /><br />then select 26th Apr 2019 announcement.<br /><br />Also researchers in Vancouver are experimenting with MSG (yes the food additive) to reduce damage to salivary grands during radio-pharmaceutical treatment in animal models.<br />Defensehttps://www.blogger.com/profile/04908662330521537612noreply@blogger.comtag:blogger.com,1999:blog-5068743626565397624.post-55523295656764653882019-05-19T23:56:53.771-07:002019-05-19T23:56:53.771-07:00I know that they are continuously working on the s...I know that they are continuously working on the salivary gland issue. Most patients carry water with all times. There are gels and pillules available at the pharmacy but the effect of these seem don't seem to be that great. Xerostomia is also caused by another diseas (I don't recall the name). My husband uses glycerine at night before bedtime so that he does have to wake up to drink water. So he manages it by eating juicy foods like fruit and salads and the occasional soup or stew for dinner. I believe most of the patients will not stop treatment just because of this. We have seen excellent results after 2 injections.Jimmy de Beerhttps://www.blogger.com/profile/17272914591223567805noreply@blogger.comtag:blogger.com,1999:blog-5068743626565397624.post-87674201784694501272018-09-21T16:58:07.422-07:002018-09-21T16:58:07.422-07:00Ra-223 has not attached well to PSMA ligands so fa...Ra-223 has not attached well to PSMA ligands so far.Allenhttps://www.blogger.com/profile/02930631057044153073noreply@blogger.comtag:blogger.com,1999:blog-5068743626565397624.post-82841041868443126582018-09-21T16:56:07.090-07:002018-09-21T16:56:07.090-07:00See the most recent (9/21/18) update for a strateg...See the most recent (9/21/18) update for a strategy for reducing the effect on salivary glands. A recent study used sialendoscopy with dilatation, saline irrigation and steroid injection to preserve salivary function:<br />https://link.springer.com/article/10.1007/s00259-018-4135-8<br />Allenhttps://www.blogger.com/profile/02930631057044153073noreply@blogger.comtag:blogger.com,1999:blog-5068743626565397624.post-36581223024775758052018-04-18T14:01:51.857-07:002018-04-18T14:01:51.857-07:00I assume that they have thought of 223Ra+PSMA and ...I assume that they have thought of 223Ra+PSMA and found it to be unworkable.Martyhttps://www.blogger.com/profile/12535061710557436016noreply@blogger.comtag:blogger.com,1999:blog-5068743626565397624.post-19548776775946527892018-04-18T14:00:13.584-07:002018-04-18T14:00:13.584-07:00I think this looks quite good to me. I would hope ...I think this looks quite good to me. I would hope that they would find a way to protect the saliva glands, possibly by a local injection of something that binds to the PMSA, such as J591, or a small molecule designed for the job.Martyhttps://www.blogger.com/profile/12535061710557436016noreply@blogger.com